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External environmental aggression - be that from UV radiation, pollution or chemicals, cause extensive skin damage and aging. Although we have other antioxidants in our products, that also help with this, Aldenine in actual fact prevents very specific free radicals - but also helps to boost the production of collagen - the foundation of your skin.
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Photo aged skin |
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Environmental factors cause the development of free radicals - which are known to be aging.
Most research has been done on ROS (Reactive Oxygen Species), a type of free radical. Yet another type, RCS (Reactive Carbonyl Species) have only recently been looked at, and the effect they have on skin deterioration and aging was also investigated.
RCS are small molecular weight carbonyls and are especially dangerous, since they are by-products of cellular metabolism including lipid peroxidation, glycation, auto-oxidation of sugars etc.
They cause DNA damage, proteosome degradation, as well as cellular and extracellular protein alterations - and most importantly - they target and destroy collagen - which we all need for firm young looking skin.
When collagen fibers are young, they are white, elastic and tough, yet with age they lose their elasticity and cross-link and become yellow. It is the cross-linking of the collagen fibers that is responsible for the hardening of the collagen and the resultant skin aging - and in this RCS are directly responsible for the cross-linking of the collagen.
One specific aldehyde (for Wikipedia's explanation of an aldehyde click here) - HNE (4-hydroxynonenal) - is found in photo damaged older skin, yet not found in young skin.
The skin can normally contend with HNE and neutralize it by means of the keratinocytes forming adducts with glutathione and in so doing neutralize the HNE.
However, when the skin has been subjected to sunlight, the glutathione is depleted and a person must look for another agent to neutralize the HNE and their RCS brothers - and this is where Aldenine plays a major part.
Aldenine, through its action in neutralizing HNE and other RCS in the skin, has a positive protection property against photo damage.
The hydrolyzed vegetal protein contained in Aldenine has also been proven to stimulate the production of collagen (collagen type III). This type of collagen is normally found in youthful skins, whereas very little collagen type III is present in older people.
The reduction of collagen III production is due to functional impairment in the skin, but with Aldenine, collagen III is boosted by 300% in just seven (7) days.
To have a look at the full clinical data of Aldenine please click here.
Active ingredients used in Créme de Vie  Articles of interest
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