Clinical research summary

Two cutting edge technologies have enabled the discovery and production of the hexapeptide molecule - Combinatorial Chemistry and Peptide Solid State Synthesis. The anti-wrinkle hexapeptide represents the discovery of a positive hit based on a scientific pathway from rational design to GMP production through the study of basic biochemical mechanisms of anti-wrinkle activity.

Clinical research was undertaken by the laboratory which developed the hexapeptide molecule, and skin topography analyses were performed on healthy women volunteers to measure the effectiveness of an O/W emulsion containing 10% of the hexapeptide.

Successful results confirmed the validation of the biochemical mechanism proposed.

Cosmetic benefits

The hexapeptide proved to reduce the depth of the wrinkles in the face caused by the contraction of the muscles of facial expression, especially around the eyes and the forehead.

It further prevents aging of the skin induced by repeated facial movements caused by excessive catecholamine release.

Effectiveness

Muscles are contracted when they receive neurotransmitters released from inside a vesicle. The SNARE (SNap REceptor) complex is essential for this neurotransmitter release at the synapses. ^{Reference 14}

It is a ternary complex formed by the proteins VAMP, Syntaxin and SNAP-25 (SyNaptosomal Associated Protein). This complex intervenes in the process of docking, fusing and exocytosis of these neurotransmitter-filled vesicles.

The hexapeptide is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation. If this SNARE complex is slightly destabilized, the vesicle is not able to release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.

Underneath the clinical results of skin topography using silicon impressions taken from the lateral preorbital area in healthy women volunteers and analyzed by confocal microscopy.

The top row illustrates the use of a placebo cream, while the bottom row illustrates the use of cream using a 10% inclusion rate of the hexapeptide. The three periods from left to right illustrates the measurements taken at day 0, day 15 and day 30.

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For further clinical data on Argireline^®

• Summary of the clinical trials done on Argireline
• The effect it has on frowns marks and wrinkles
• The anti-wrinkle and anti-aging effect
• Results of the anti-wrinkle test done on humans
• Chromaffin cell cultures and secretion assays
• Synthesis and purification of the Peptide
• Clinical references
• Recombinant SNARE proteins expression and purification

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